Germ Cell Apoptosis: Clinical Implications
نویسندگان
چکیده
منابع مشابه
Regulation of Male Germ Cell Apoptosis
Testicular tissue is extremely sensitive to external stress such as cancer treatments, which induce inappropriate germ cell apoptosis leading to defects in reproductive health (1, 2). For postpubertal men, cryopreservation of sperm or testicular tissue is a proven method for preserving fertility against the effects of these treatments (3). Unfortunately, no such method exists for prepubertal bo...
متن کاملGerm cell apoptosis and DNA damage responses.
In the past 12 years, since the first description of C. elegans germ cell apoptosis, this area of research rapidly expanded. It became evident that multiple genetic pathways lead to the apoptotic demise of germ cells. We are only beginning to understand how these pathways that all require the CED-9/Bcl-2, Apaf-1/CED-4 and CED-3 caspase core apoptosis components are regulated. Physiological apop...
متن کاملMale germ cell apoptosis: regulation and biology.
Cellular apoptosis appears to be a constant feature in the adult testis and during early development. This is essential because mammalian spermatogenesis is a complex process that requires precise homeostasis of different cell types. This review discusses the latest information available on male germ cell apoptosis induced by hormones, toxins and temperature in the context of the type of apopto...
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BACKGROUND Cadmium (Cd) is a common environmental pollutant and a major constituent of tobacco smoke. Adverse effects of this heavy metal on reproductive function have been identified in adults; however, no studies have examined its effects on human reproductive organs during development. OBJECTIVES Using our previously developed organ culture system, we investigated the effects of cadmium ch...
متن کاملRapamycin protects testes against germ cell apoptosis and oxidative stress induced by testicular ischemia-reperfusion
Objective(s):Rapamycin is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. The purpose of the present study was to examine the effect of rapamycin on testicular ischemia-reperfusion injury. Materials and Methods: Seventy-two adult male Wistar rats w...
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ژورنال
عنوان ژورنال: Andrology-Open Access
سال: 2014
ISSN: 2167-0250
DOI: 10.4172/2167-0250.1000122